![]() It also targets those diseases which are driven by pathways which match the host-response profile of the strain.ĤD Pharma say that traditional pharmaceutical drug discovery involves multiple rounds of hit and lead optimisation to identify a clinical candidate – a process which can take many years. ![]() ![]() MicroRx interrogates the firm’s library of bacterial isolates for therapeutic functionality by first identifying strains which have significant effects on the host The firm’s MicroRx platform specifically selects those bacteria that have a therapeutic effect in certain diseases. “By applying 4D’s MicroRx technology we hope to gain meaningful insights into the role for the host microbiome in modulating the immune response and ultimately protection conferred by vaccines.” “A key element of our focus in the Exploratory Science Center is the evaluation of emerging new areas of biology that have the potential to offer major beneficial impact to human health,” says Daria Hazuda, chief scientific officer of MSD’s Exploratory Science Center Meanwhile, MSD’s responsibilities include product development, manufacturing and commercialisation following the exercise of any of its exclusive options. Under the agreement’s financial terms, 4D are entitled to an upfront cash payment, for each indication with the UK firm eligible to receive up to €312m in development and regulatory milestone payments.ĤD Pharma will also qualify for tiered royalties on annual net sales of any licensed products derived from the collaboration. “MSD and 4D have worked closely combining world leading science to develop a workplan to advance the understanding of this field, with the aim of generating a new class of vaccines in areas of high unmet need.” “This research collaboration agreement brings together 4D’s innovation in the microbiome space and MSD’s track record of developing cutting-edge vaccines,” says Duncan Peyton, 4D’s chief executive officer. The deal looks to pair 4D’s MicroRx platform with MSD’s vaccine expertise develop Live Biotherapeutics (LBPs) as vaccines. The gut-brain axis: Psychobiotic opportunity in 25 countries.Uncovering white spaces – Probiotics for a smooth menopause transition.Uncovering White Spaces – Probiotics for Pets.POSTbiotics – New Tools in Microbiome Modulation.After the pandemic: Business lessons and insights from 25 probiotic supplement e-markets.
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